Canine N-terminal B-type brain natriuretic peptide precursor is secreted by myocardial cells in the canine ventricle, and can be used as a detection indicator of the corresponding heart failure. The concentration of cNT-proBNP in the blood is related to the severity of the disease. Therefore, NT-proBNP can not only evaluate the severity of acute and chronic heart failure, but also serve as an indicator of its prognosis.
This product uses fluorescence immunochromatography to detect the content of cNT-proBNP in serum/plasma quantitatively. Basic principle: There are T and C lines on the nitric acid fiber membrane respectively, and the T line is coated with antibody a that specifically recognizes cNT-proBNP. The combination pad is sprayed with another fluorescent nanomaterial labeled antibody b that can specifically identify cNT-proBNP. In the sample, cNT-proBNP first combines with the nanomaterial labeled antibody b to form a complex, and then to the upper chromatography, the complex combines with the T-line antibody A to form a sandwich structure. When the
excitation of light irradiation, the nanomaterial emits fluorescence signals. The strength of the signal is positively correlated with the concentration of cNT-proBNP in the sample.
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